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1993 1
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Page 1
A new association between CDK5RAP2 microcephaly and congenital cataracts.
Alfares A, Alhufayti I, Alsubaie L, Alowain M, Almass R, Alfadhel M, Kaya N, Eyaid W. Alfares A, et al. Ann Hum Genet. 2018 May;82(3):165-170. doi: 10.1111/ahg.12232. Epub 2017 Dec 22. Ann Hum Genet. 2018. PMID: 29271474
INTRODUCTION: Primary microcephaly type 3 is a genetically heterogeneous condition caused by a homozygous or compound heterozygous mutation in CDK5 regulatory subunit associated protein 2 (CDK5RAP2) and characterized by reduced head circumference (<5th percentile …
INTRODUCTION: Primary microcephaly type 3 is a genetically heterogeneous condition caused by a homozygous or compound heterozygous mutation …
Centromeric chromatin integrity is compromised by loss of Cdk5rap2, a transcriptional activator of CENP-A.
Wang X, Rosales JL, Gao X, Lee KY. Wang X, et al. Biomed Pharmacother. 2021 Jun;138:111463. doi: 10.1016/j.biopha.2021.111463. Epub 2021 Mar 13. Biomed Pharmacother. 2021. PMID: 33725591 Free article.
This prompted us to investigate a potential link between CENP-A and Cdk5rap2 in the maintenance of centromeric chromatin integrity. Here, we demonstrate that loss of Cdk5rap2 causes reduced CENP-A expression while exogenous Cdk5rap2 expression in cells deplet …
This prompted us to investigate a potential link between CENP-A and Cdk5rap2 in the maintenance of centromeric chromatin integrity. H …
The smallest of the small.
Hall JG. Hall JG. Gene. 2013 Oct 1;528(1):55-7. doi: 10.1016/j.gene.2013.03.081. Epub 2013 Apr 10. Gene. 2013. PMID: 23583796
Transient response to imatinib in a chronic eosinophilic leukemia associated with ins(9;4)(q33;q12q25) and a CDK5RAP2-PDGFRA fusion gene.
Walz C, Curtis C, Schnittger S, Schultheis B, Metzgeroth G, Schoch C, Lengfelder E, Erben P, Müller MC, Haferlach T, Hochhaus A, Hehlmann R, Cross NC, Reiter A. Walz C, et al. Genes Chromosomes Cancer. 2006 Oct;45(10):950-6. doi: 10.1002/gcc.20359. Genes Chromosomes Cancer. 2006. PMID: 16845659
CDK5RAP2 encodes a protein that is believed to be involved in centrosomal regulation. The predicted CDK5RAP2-PDGFRA protein consists of 1,003 amino acids and retains both tyrosine kinase domains of PDGFRA and several potential dimerization domains of CDK5RAP2 …
CDK5RAP2 encodes a protein that is believed to be involved in centrosomal regulation. The predicted CDK5RAP2-PDGFRA protein co …
Primary Autosomal Recessive Microcephalies and Seckel Syndrome Spectrum Disorders – RETIRED CHAPTER, FOR HISTORICAL REFERENCE ONLY.
Verloes A, Drunat S, Gressens P, Passemard S. Verloes A, et al. 2009 Sep 1 [updated 2013 Oct 31]. In: Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE, Bean LJH, Gripp KW, Amemiya A, editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993–2024. 2009 Sep 1 [updated 2013 Oct 31]. In: Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE, Bean LJH, Gripp KW, Amemiya A, editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993–2024. PMID: 20301772 Free Books & Documents. Review.
The genes in which biallelic mutation is known to cause MCPH-SCKS spectrum disorders are separated into those that are currently known to be associated with: MCPH phenotype only: MCPH1 (locus name MCPH1), WDR62 (MCPH2), CDK5RAP2 (MCPH3), KNL1 (MCPH4), ASPM (MCPH5), STIL (M …
The genes in which biallelic mutation is known to cause MCPH-SCKS spectrum disorders are separated into those that are currently known to be …
Microtubule plus-end tracking of end-binding protein 1 (EB1) is regulated by CDK5 regulatory subunit-associated protein 2.
Fong KW, Au FKC, Jia Y, Yang S, Zhou L, Qi RZ. Fong KW, et al. J Biol Chem. 2017 May 5;292(18):7675-7687. doi: 10.1074/jbc.M116.759746. Epub 2017 Mar 20. J Biol Chem. 2017. PMID: 28320860 Free PMC article.
We show here that an interaction of EB1 with the SXIP-containing +TIP CDK5 regulatory subunit-associated protein 2 (CDK5RAP2) regulates several EB1 activities, including microtubule plus-end tracking, dynamics at microtubule plus ends, microtubule and alpha/beta-tub …
We show here that an interaction of EB1 with the SXIP-containing +TIP CDK5 regulatory subunit-associated protein 2 (CDK5RAP2) …
The DNA replication protein Cdc6 inhibits the microtubule-organizing activity of the centrosome.
Lee I, Kim GS, Bae JS, Kim J, Rhee K, Hwang DS. Lee I, et al. J Biol Chem. 2017 Sep 29;292(39):16267-16276. doi: 10.1074/jbc.M116.763680. Epub 2017 Aug 21. J Biol Chem. 2017. PMID: 28827311 Free PMC article.
This increase and decrease in microtubule nucleation correlated with the centrosomal intensities of PCM proteins such as gamma-tubulin, pericentrin, CDK5 regulatory subunit-associated protein 2 (CDK5RAP2), and centrosomal protein 192 (Cep192). ...
This increase and decrease in microtubule nucleation correlated with the centrosomal intensities of PCM proteins such as gamma-tubulin, peri …
The Golgi apparatus is the main microtubule-organizing center in differentiating skeletal muscle cells.
Ide K, Muko M, Hayashi K. Ide K, et al. Histochem Cell Biol. 2021 Sep;156(3):273-281. doi: 10.1007/s00418-021-01999-6. Epub 2021 Jun 10. Histochem Cell Biol. 2021. PMID: 34110464
In microtubule regrowth assay, microtubule regrowth after cold-nocodazole depolymerization of preexisting microtubules was not found at the gap of the perinuclear Golgi apparatus. Most of the microtubule regrowth was detected at the CDK5RAP2 (CDK5 regulatory subunit …
In microtubule regrowth assay, microtubule regrowth after cold-nocodazole depolymerization of preexisting microtubules was not found at the …
Dishevelled is a NEK2 kinase substrate controlling dynamics of centrosomal linker proteins.
Cervenka I, Valnohova J, Bernatik O, Harnos J, Radsetoulal M, Sedova K, Hanakova K, Potesil D, Sedlackova M, Salasova A, Steinhart Z, Angers S, Schulte G, Hampl A, Zdrahal Z, Bryja V. Cervenka I, et al. Proc Natl Acad Sci U S A. 2016 Aug 16;113(33):9304-9. doi: 10.1073/pnas.1608783113. Epub 2016 Aug 2. Proc Natl Acad Sci U S A. 2016. PMID: 27486244 Free PMC article.
DVL accumulates during the cell cycle and associates with NIMA-related kinase 2 (NEK2), which is able to phosphorylate DVL at a multitude of residues, as detected by a set of novel phospho-specific antibodies. This creates interfaces for efficient binding to CDK5 regulator …
DVL accumulates during the cell cycle and associates with NIMA-related kinase 2 (NEK2), which is able to phosphorylate DVL at a multitude of …
Activation of Aurora-A is essential for neuronal migration via modulation of microtubule organization.
Takitoh T, Kumamoto K, Wang CC, Sato M, Toba S, Wynshaw-Boris A, Hirotsune S. Takitoh T, et al. J Neurosci. 2012 Aug 8;32(32):11050-66. doi: 10.1523/JNEUROSCI.5664-11.2012. J Neurosci. 2012. PMID: 22875938 Free PMC article.
We found that CDK5RAP2 is a key molecule that mediates functional interaction and is essential for centrosomal targeting of Aurora-A. Our observations demonstrated novel and surprising cross talk between Aurora-A and CDK5 during neuronal migration....
We found that CDK5RAP2 is a key molecule that mediates functional interaction and is essential for centrosomal targeting of Aurora-A. …
12 results